O.M. Stewart Colloquium Series

Monday, October 16, 2017 4:00pm

Physics Library, Room 223A, Physics Building

Departments: 

Prof. Andrew Gu

Prof. Andrew Gu, University of Missouri - Columbia, Biological Engineering, presents, "Nanopore Force Spectroscopy of Biomolecular Interactions: Application in Biomedical Detection," Monday, Oct. 16 at 4:00 p.m. in the Physics Library. Refreshments will be served at 3:30 p.m.

"Precision medicine is a new approach for disease treatment and prevention (in particular cancer) via a personalized strategy based on the molecular abnormalities in genes, proteins, and metabolites for each person. President Obama’s $215 million Precision Medicine Initiative® (2015) is motivating the development of new-generation technologies for accurate measurement and systematic analysis of individual’s genetic, epigenetic, proteomic and metabolic profiles. Our lab is working on a nanopore-based single-molecule technology (electrochemical measurement) for rapid, label-free and low-cost DNA sequencing and various genetic, epigenetic, and proteomic detections. The new generation of programmable nanopore biosensors is being combined with smart polymers and microfludics to create robust chip device for medical diagnosis, treatment, and high-throughput screening at the molecular level.

These explorations are exemplified by, but not limited to, 1) the nanopore detection of cancer-associated circulating non-coding RNAs epigenetic biomarkers such as microRNAs, offering non-invasive, cost-effective and accurate tools for confirmatory cancer detection; and 2) nanopore force toolbox: from mechanistic study of RNA folding/unfolding to clinical detection of RNA biomarkers. The overall research has broad impact toward precision medicine and life science."